Syringe Adapter for Closed Transfer of Fluids

ABSTRACT

A syringe adapter includes a housing, a cannula having a first end and a second end with the second end of the cannula positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway with a membrane received by the passageway. The collet includes a locking member connected to the body of the collet. The membrane includes a body having a first end and a second end with the collet movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted. The passageway of the body of the collet includes a narrowed portion configured to compress a portion of the body of the membrane.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to U.S. Provisional Application Ser.No. 62/447,038, filed Jan. 17, 2017, which is hereby incorporated byreference in its entirety.

BACKGROUND OF THE INVENTION Field of the Disclosure

The present disclosure relates generally to a system for the closedtransfer of fluids. More particularly, the present disclosure relates toa system that provides leak-proof sealing during fluid transfer from afirst container to a second container.

Description of the Related Art

Health care providers reconstituting, transporting, and administeringhazardous drugs, such as cancer treatments, can put health careproviders at risk of exposure to these medications and present a majorhazard in the health care environment. For example, nurses treatingcancer patients risk being exposed to chemotherapy drugs and their toxiceffects. Unintentional chemotherapy exposure can affect the nervoussystem, impair the reproductive system, and bring an increased risk ofdeveloping blood cancers in the future. In order to reduce the risk ofhealth care providers being exposed to toxic drugs, the closed transferof these drugs becomes important.

Some drugs must be dissolved or diluted before they are administered,which involves transferring a solvent from one container to a sealedvial containing the drug in powder or liquid form, by means of a needle.Drugs may be inadvertently released into the atmosphere in gas form orby way of aerosolization, during the withdrawal of the needle from thevial and while the needle is inside the vial if any pressuredifferential between the interior of the vial and the surroundingatmosphere exists.

SUMMARY OF THE INVENTION

In one aspect, a syringe adapter includes a housing having a first endand a second end with the first end configured to be secured to a firstcontainer, a cannula having a first end and a second end with the secondend of the cannula positioned within the housing, and a collet having afirst end and a second end with at least a portion of the colletreceived within the housing. The collet includes a body defining apassageway with a membrane received by the passageway. The colletincludes a locking member connected to the body of the collet. Themembrane includes a body having a first end and a second end with thecollet movable from a first position where the locking member is open toreceive a mating connector to a second position where radially outwardmovement of the locking member is restricted. The passageway of the bodyof the collet includes a narrowed portion configured to compress aportion of the body of the membrane.

The passageway of the body of the collet may include a firstcounterbore, a second counterbore positioned opposite the firstcounterbore, and an intermediate portion, with the intermediate portionof the passageway of the body of the collet including the narrowedportion. The passageway may have a smaller diameter than a remainingportion of the intermediate portion of the passageway. The membrane mayhave a first head portion and a second head portion, with the first andsecond head portions extending radially outward from the body of themembrane, and the body of the membrane having a first portion having afirst diameter and a second portion having a second diameter. The firstdiameter may be smaller than the second diameter. The intermediateportion of the passageway of the body of the collet may receive thefirst portion of the membrane. The second counterbore of the passagewayof the body of the collet may receive the second portion of themembrane.

The body of the membrane may define a passageway that may extend fromthe first end of the body of the membrane towards the second end of thebody of the membrane. The passageway of the membrane may terminate at aposition intermediate the first and second ends of the body of themembrane.

The membrane may include a first head portion and a second head portion.The first head portion of the membrane may be positioned within thepassageway of the collet, with the second head portion engaged with anend of the body of the collet. The first head portion may include afrusto-conical surface. The second head portion may include a convexsurface. The first head portion of the membrane may engage the colletand may be positioned within the first counterbore.

The passageway of the collet may have a first portion and a secondportion, with the first portion of the passageway including the narrowedportion. The first portion of the passageway of the collet may have asmaller diameter than the second portion of the passageway of thecollet.

BRIEF DESCRIPTION OF THE DRAWINGS

The above-mentioned and other features and advantages of thisdisclosure, and the manner of attaining them, will become more apparentand the disclosure itself will be better understood by reference to thefollowing descriptions of aspects of the disclosure taken in conjunctionwith the accompanying drawings, wherein:

FIG. 1 is a cross-sectional view of a syringe adapter according to oneaspect of the present invention.

FIG. 2 is a cross-sectional view of a syringe adapter according to oneaspect of the present invention.

FIG. 3 is a perspective view of a collet according to one aspect of thepresent invention.

FIG. 4 is a cross-sectional view of the collet of FIG. 3.

FIG. 5 is a front view of a system for the closed transfer of fluidsaccording to one aspect of the present invention.

FIG. 6 is a cross-sectional view of the system of FIG. 5.

FIG. 7A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 7B is a cross-sectional view of the first membrane of FIG. 7A.

FIG. 8A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 8B is a cross-sectional view of the first membrane of FIG. 8A.

FIG. 9A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 9B is a cross-sectional view of the first membrane of FIG. 9A.

FIG. 10A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 10B is a cross-sectional view of the first membrane of FIG. 10A.

FIG. 11A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 11B is a cross-sectional view of the first membrane of FIG. 11A.

FIG. 12A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 12B is a cross-sectional view of the first membrane of FIG. 12A.

FIG. 13A is a front view of a first membrane according to one aspect ofthe present invention.

FIG. 13B is a cross-sectional view of the first membrane of FIG. 13A.

FIG. 14A is a front view of a second membrane according to one aspect ofthe present invention.

FIG. 14B is a cross-sectional view of the second membrane of FIG. 14A.

FIG. 15A is a front view of a second membrane according to one aspect ofthe present invention.

FIG. 15B is a cross-sectional view of the second membrane of FIG. 15A.

FIG. 16A is a front view of a second membrane according to one aspect ofthe present invention.

FIG. 16B is a cross-sectional view of the second membrane of FIG. 16A.

FIG. 17A is a front view of a second membrane according to one aspect ofthe present invention.

FIG. 17B is a cross-sectional view of the second membrane of FIG. 17A.

FIG. 18A is a front view of a second membrane according to one aspect ofthe present invention.

FIG. 18B is a cross-sectional view of the second membrane of FIG. 18A.

FIG. 19A is a front view of a second membrane according to one aspect ofthe present invention.

FIG. 19B is a cross-sectional view of the second membrane of FIG. 19A.

FIG. 20 is a front view of a system for the closed transfer of fluidsaccording to one aspect of the present invention.

FIG. 21 is a cross-sectional view of system shown in FIG. 20.

FIG. 22 is a cross-sectional view of a syringe adapter according to oneaspect of the present invention.

FIG. 23 is a cross-sectional view of a syringe adapter according to oneaspect of the present invention.

FIG. 24 is a front view of a syringe adapter according to one aspect ofthe present invention.

FIG. 25 is a front view of a system for the closed transfer of fluidsaccording to one aspect of the present invention.

FIG. 26 is a cross-sectional view of the system of FIG. 25.

FIG. 27 is a cross-sectional view of the system of FIG. 25, showing apatient connector secured to a syringe adapter.

FIG. 28 is a top view of the patient connector of FIG. 25 according toone aspect of the present invention.

FIG. 29 is an enlarged cross-sectional view of the system of FIG. 25,showing a patient connector secured to a syringe adapter.

FIG. 30 is a perspective view of a system for the closed transfer offluids according to one aspect of the present invention.

FIG. 31 is a cross-sectional view of the system of FIG. 30.

FIG. 32 is a cross-sectional view of the system of FIG. 30, showing apatient connector secured to a syringe adapter with a lock mechanism inan unlocked position.

FIG. 33 is a perspective view of the system of FIG. 30, showing apatient connector secured to a syringe adapter with a lock mechanism ina locked position.

FIG. 34 is a cross-sectional view of the system of FIG. 30, showing apatient connector secured to a syringe adapter with a lock mechanism ina locked position.

FIG. 35 is an exploded, perspective view of the system of FIG. 30according to one aspect of the present invention.

Corresponding reference characters indicate corresponding partsthroughout the several views. The exemplifications set out hereinillustrate exemplary aspects of the disclosure, and suchexemplifications are not to be construed as limiting the scope of thedisclosure in any manner.

DETAILED DESCRIPTION

The following description is provided to enable those skilled in the artto make and use the described aspects contemplated for carrying out theinvention. Various modifications, equivalents, variations, andalternatives, however, will remain readily apparent to those skilled inthe art. Any and all such modifications, variations, equivalents, andalternatives are intended to fall within the spirit and scope of thepresent invention.

For purposes of the description hereinafter, the terms “upper”, “lower”,“right”, “left”, “vertical”, “horizontal”, “top”, “bottom”, “lateral”,“longitudinal”, and derivatives thereof shall relate to the invention asit is oriented in the drawing figures. However, it is to be understoodthat the invention may assume various alternative variations, exceptwhere expressly specified to the contrary. It is also to be understoodthat the specific devices illustrated in the attached drawings, anddescribed in the following specification, are simply exemplary aspectsof the invention. Hence, specific dimensions and other physicalcharacteristics related to the aspects disclosed herein are not to beconsidered as limiting.

Referring to FIG. 1, a syringe adapter 12 according to one aspect of thepresent invention is shown. The syringe adapter 12 is one component of asystem for the closed transfer of fluids. In particular, the syringeadapter 12 is configured to connect to a syringe (not shown) to anothermedical device or fluid container. The medical device can be, forexample, a patient line, vial adapter, fluid container, or infusionadapter. In other examples, the container can be a medical vial, syringebarrel, IV bag, or similar container for holding a fluid to beadministered to a patient. The syringe adapter 12 can be used tofacilitate the closed transfer of fluids between the syringe and medicaldevice or fluid container. The syringe adapter 12 is similar to andoperates in a similar manner as the syringe adapter shown and describedin United States Patent Application Publication No. 2015/0297454, whichis hereby incorporated by reference in its entirety.

Referring again to FIG. 1, the syringe adapter 12 includes a housing 16having a first end 18 and a second end 20 and defining an interior space22. The first end 18 of the housing 16 of the syringe adapter 12includes a syringe attachment 24, such as a female luer connector, thatdefines a passageway 26. Although a female luer connector is shown forconnection with a corresponding male luer connector of a syringe (notshown), other suitable connection arrangements may be utilized forconnection to a syringe, container, or any other medical device. Acannula 28 having a distal end 30 is secured to the syringe attachment24 and in fluid communication with the passageway 26 of the syringeattachment 24. The syringe adapter 12 further includes a sealarrangement positioned within the housing 16 of the syringe adapter 12.The seal arrangement includes a collet 32 that receives a first membrane34. The collet 32 is configured to move within the interior space 22 ofthe housing 16 of the syringe adapter 12 as discussed in more detailbelow. The housing 16 of the syringe adapter 12 may include structure toenhance gripping of the syringe adapter 12 by a user. Additional oralternative grip structures and surfaces may be provided to assist auser in gripping the body of the syringe adapter 12.

The syringe adapter 12 includes a first connection interface 36positioned intermediate the first and second ends 18, 20 of the housing16 of the syringe adapter 12 that includes a lock member 38 that isreceived within a transverse opening 40 in the housing 16 of the syringeadapter 12. The lock member 38 is configured to move between a closedposition and an open position. The lock member 38 further includes acantilever spring 46 that extends in a longitudinal direction of thesyringe adapter 12. The lock member 38 is configured to engage a camsurface that extends radially outward from the housing 16 of the syringeadapter 12. In particular, the lock member 38 is configured to beprovided in the closed position, where a portion of the lock member 38adjacent to a central opening of the lock member 38 is positioned withinthe interior space 22 of the syringe adapter 12 when no external forcesare applied to the lock member 38. When the lock member 38 is moved tothe open position where central opening of the lock member 38 is alignedwith the interior space 22 of the syringe adapter 12 or does not createan interference or barrier to objects being inserted into the interiorspace 22, the cantilever spring 46 engages the cam surface to create abiasing force that urges the lock member 38 back towards the closedposition. Accordingly, when the lock member 38 is moved to the openposition, the lock member 38 will be urged back to the closed positionwhen the external force acting on the lock member 38 is released.Although the lock member 38 is shown with the cantilever spring 46, anyother suitable biasing member may be provided including, but not limitedto, compression springs, extension springs, elastomeric material, etc.

Referring to FIGS. 1 and 3, the collet 32 has a body 52 with a first end54 and a second end 56. The body 52 defines a passageway 58 that extendsthrough the body 52. The body 52 is generally cylindrical, althoughother suitable shaped collets may be utilized. The collet 32 furtherincludes a locking member 60 connected to the body 52 of the collet 32.The collet 32 is movable from a first position where the locking member60 is open to receive a mating connector, such as a patient connector,to a second position where radially outward movement of the lockingmember 60 is restricted. The locking member 60 is connected to the body52 via a plurality of arms 62. The locking member 60 is arcuate andresilient as a result of the connection of the locking member 60 to thebody 52 via the plurality of arms 62. More specifically, the pluralityof arms 62 are flexible and allow the locking member 60 to expandradially outward or radially inward. In one aspect, the locking member60 is configured to expand radially outward when a mating connector,such as a patient connector, is inserted into the locking member 60 andsubsequently moving radially inward as the collet 32 is transitionedfrom the first position to the second position. Alternatively, thelocking member 60 may not move radially inward or outward when a matingconnector is inserted into the locking member 60 and may subsequentlymove radially inward as the collet 32 is transitioned from the firstposition to the second position. The second end 20 of the housing 16 ofthe syringe adapter 12 defines an annular recess 64 adjacent to theinterior space 22 that receives the locking member 60 when the collet 32is in the first position. The annular recess 64 of the housing 16provides the space for the locking member 60 to expand radially outward.When the collet 32 is transitioned from the first position to the secondposition, the collet 32 moves axially toward the first end 18 of thesyringe adapter 12 with the locking member 60 being biased radiallyinward due to the engagement of the locking member 60 with the housing16 of the syringe adapter 12.

As shown in FIG. 3, the locking member 60 of the collet 32 defines apair of openings 66 that extend in a direction perpendicular to alongitudinal axis of the collet 32. The openings 66 bifurcate thelocking member 60 into two arcuate portions that are each connected tothe body 52 of the collet 32 by two arms 62. However, other suitablearrangements and shapes for the collet 32 and the locking member 60 maybe utilized. The locking member 60 of the collet 32 protrudes radiallyinward and radially outward relative to the plurality of arms 62.

Referring again to FIGS. 1 and 3, the body 52 of the collet 32 includesa second connection interface 70 that is configured to mate with andlock with the first connection interface 36 of the syringe adapter 12.The second connection interface 70 is defined by the body 52 of thecollet 32. The first end 54 of the collet 32 is configured to bereceived within the interior space 22 of the syringe adapter 12 when thelock member 38 of the first connection interface 36 is in the openposition and restricted from moving within the interior space 22 of thesyringe adapter 12 when the lock member 38 is in the closed position.When the second connection interface 70 is fully mated to the firstconnection interface 36, the lock member 38 of the first connectioninterface 36 is configured to be in the closed position to lock thefirst connection interface 36 from longitudinal and transverse movementrelative to the second connection interface 70, but still allowingrotational movement relative thereto.

Referring to FIG. 1, the passageway 58 of the body 52 of the collet 32includes a first counterbore 68, a second counterbore 74, positionedopposite the first counterbore 68, and an intermediate portion 76positioned between the first and second counterbores 68, 74.

Referring to FIG. 3, the body of the collet 32 also includes a pluralityof ribs 78 positioned intermediate the first end 54 and the second end56. The ribs 78 extending longitudinally, although other suitableconfigurations may be utilized. A plurality of recesses 80 arepositioned between adjacent ribs 78.

Referring to FIGS. 2-6, in one aspect of the present invention, thepassageway 58 of the body of the collet 32 includes a narrowed portion79 configured to compress a portion of the first membrane 34. In oneaspect, the intermediate portion 76 of the passageway 58 of the body 52of the collet 32 includes the narrowed portion 79. The narrowed portion79 of the passageway 58 has a smaller diameter than a remaining portionof the intermediate portion 76 of the passageway 58.

Referring to FIGS. 2 and 6, the first membrane 34 includes a body 82having a first end 84 and a second end 86. The first end 84 and thesecond end 86 of the body 82 of the first membrane 34 include a firsthead portion 88 and a second head portion 90, respectively. The body 82of the first membrane 34 defines a passageway 92 extending from thefirst end 84 towards the second end 86 of the body 82. The passageway 92terminates at a position intermediate the first and second ends 84, 86of the body 82. The body 82 of the first membrane 34 also defines anannular recessed portion 87 positioned intermediate the first and secondends 84, 86. The body 82 of the first membrane 34 is received by thepassageway 58 of the collet 32 and is secured to the collet 32. Thefirst head portion 88 of the first membrane 34 engages the firstcounterbore 68 of the collet 32. The second head portion 90 extendsbeyond the passageway 58 of the body 52 of the collet 32 with the secondhead portion 90 engaging the body 52 of the collet 32. The annularrecessed portion 87 of the first member 34 is received by theintermediate portion 76 of the collet 32 with the narrowed portion 79engaging and compressing the annular recessed portion 87 of the firstmember 34.

The second head portion 90 defines a convex surface, although othersuitable membrane arrangements may be provided as discussed in moredetail below. The cannula 28 is received within the passageway 92 of thefirst membrane 34 with the distal end 30 of the cannula 28 positionedwithin the passageway 92 when the collet 32 is in the first position.The distal end 30 of the cannula 28 is configured to pierce the firstmembrane 34 and extend through the first membrane 34 when the collet 32is transitioned from the first position to the second position. Thefirst membrane 34 is configured to engage and seal an intermediateportion of the cannula 28 during use of the syringe adapter 12 tomaintain a sealed and leak-free connection with a mating component.

Upon engagement of the first membrane 34 by a corresponding membraneduring use, such as a second membrane 94 from the patient connector 96,a vial adapter, or IV bag spike, the collet 32 is configured to movetoward the first end 18 of the syringe adapter 12 and transition fromthe first position to the second position such that the distal end 30 ofthe cannula 28 pierces the first membrane 34 to place the syringeadapter 12 in fluid communication with corresponding devices secured tothe syringe adapter 12. When the collet 32 is returned to the firstposition, the first membrane 34 can be disengaged from the correspondingmembrane thereby positioning the distal end 30 of the cannula 28 withinthe passageways 58, 92 of the collet 32 and the first membrane 34. Suchan arrangement shields the distal end 30 of the cannula 28 to preventaccidental needle sticks and also prevents the leakage of any fluidduring transfer of fluids when using the syringe adapter 12.

Referring to FIGS. 5 and 6, the patient connector 96 includes a body 102having a first end 104 and a second end 106 and defining a passageway108 that extends therethrough. The first end 104 of the patientconnector 96 also includes a collet interface 110. The collet interface110 is defined by a portion of the body 102 of the patient connector 96that is recessed relative to the first end 104 of the body 102 of thepatient connector 96. The first end 104 of the body 102 of the patientconnector 96 also includes a membrane seat 112 that receives a secondmembrane 94. As discussed above in connection with the syringe adapter12, the second membrane 94 of the patient connector 96 is configured toengage the first membrane 34 of the syringe adapter 12 and provide asubstantially leak-free connection with the syringe adapter 12 duringfluid transfer. The second end 106 of the patient connector 96 includesan IV line attachment, such as a male luer connector, although any othersuitable connection arrangement may be utilized.

Referring to FIGS. 2 and 6, as discussed above, the narrowed portion 79of the passageway of the body 52 of the collet 32 compresses the firstmembrane 34. In particular, the narrowed portion 79 compresses theannular recessed portion 89 of the first membrane 34. During use of thesyringe adapter 10, back pressure acting on the first membrane 34 couldpotentially unseat the first membrane 34 from the collet 32. Thenarrowed portion 79 acts as a back pressure resistance feature byapplying additional compression between the collet 32 and the firstmembrane 34.

Referring to FIGS. 7A-13B, further aspects of the first membrane 34 areshown. In particular, various shapes, configurations, and cavities maybe utilized for the first membrane 34. The geometries shown in FIGS.7A-13B may be pushed or pulled into a mating component and retainedwithout the need for secondary assembly processes or multi-piecehousings. The passageway 92 of the first membrane may include variousshapes, lengths, widths, and configurations. Further, as shown in FIGS.12-13B, the first end 84 of the first membrane 34 may not include a headportion or radial projections.

Referring to FIGS. 14A-19B, further aspects of the second membrane 94are shown. In particular, various shapes and configurations may beutilized for the second membrane 94. As shown in FIGS. 17A and 17B, thesecond membrane 94 may include an annular recess 98.

Referring to FIGS. 21-24, a syringe adapter 120 and patient connector122 according to a further aspect of the present invention is shown. Thesyringe adapter 120 is similar to the syringe adapter 12 shown in FIG. 1and operates in a similar manner. The syringe adapter 120 and patientconnector 122 of FIGS. 21-24, however, include a different connectionarrangement. In particular, rather than providing the first and secondconnection interfaces 36, 70, the patient connector 122 includes alocking mechanism 124 having a biasing member 126 and an engagementmember 128 positioned on the biasing member 126. The engagement member128 is configured to engage a portion of the housing 16 of the syringeadapter 120 to secure the patient connector 122 to the syringe adapter120 when the patient connector 122 is received by the syringe adapter120. Although the locking mechanism 124 is shown in connection with thepatient connector 122, the locking mechanism 124 may be provided on anysuitable component of a system for the closed transfer of fluids,including, but not limited to, vial adapters, infusion adapters, etc.

The biasing member 126 of the locking mechanism 124 is a cantilever arm,although other suitable biasing arrangements may be utilized. Theengagement member 128 is a projection extending radially outwards fromthe patient connector 122, although other suitable projections may beutilized. The engagement member 128 is configured to engage a portion ofthe housing 16 of the syringe adapter 120 to bias the engagement member128 radially inward via the cantilever arm during insertion of thepatient connector 122 into the syringe adapter 120. The engagementmember 128 is also configured to return to a non-biased position whenthe patient connector 122 has been fully inserted into the syringeadapter 120 to secure the patient connector 122 to the syringe adapter120. Accordingly, upon inserting the patient connector 122 into thehousing 16 of the syringe adapter 120, the biasing member 126 isdeflected radially inward through engagement of the engagement member128 with the housing 16 of the syringe adapter 120. Once fully inserted,the biasing member 126 returns to the non-biased position with theengagement member 128 retaining the patient connector 122 in the syringeadapter 120 with the collet 32 engaged with the collet interface 110 ofthe patient connector 122. To remove the patient connector 122, a userapplies an axial force to the patient connector 122 in a direction awayfrom the syringe adapter 120 such that the biasing member 126 is againdeflected radially inward through engagement of the engagement member128 with the housing 16 of the syringe adapter 120 until the engagementmember 128 is axially displaced beyond the housing 16 of the syringeadapter 120. The collet 32 will also release from the patient connector122 in the same manner as discussed above in connection with syringeadapter 12.

Referring to FIGS. 21 and 23, the syringe adapter 120 may also include acollet drive member 132 configured to bias the collet 32 toward thesecond end 20 of the syringe adapter 120 to maintain the collet 32 inthe first position. The syringe adapter 120 operates in the same manneras discussed above in connection with syringe adapter 12, but the colletdrive member 132 requires a user to overcome the biasing force of thecollet drive member 132 to move the collet 32 from the first position tothe second position when the syringe adapter 120 is mated with a matingconnector, such as the patient connector 122. The collet drive member132 may be a spring, although other suitable biasing arrangements may beutilized. Further, as shown in FIGS. 21-23, the collet 32 may notinclude the first counterbore 68 with the first end 54 of the colletdefining a planar surface 134.

Referring to FIGS. 25-29, a syringe adapter 150 and patient connector152 according to a further aspect of the present invention is shown. Thesyringe adapter 150 is similar to the syringe adapter 12 shown in FIG. 1and operates in a similar manner. The syringe adapter 150 and patientconnector 152 of FIGS. 25-29, however, include a different connectionarrangement. In particular, rather than providing the first and secondconnection interfaces 36, 70, the patient connector 152 includes aconnection member 154. The connection member 154 is configured to engagea portion of the housing 16 of the syringe adapter 150 to secure thepatient connector 152 to the syringe adapter 150 when the patientconnector 152 is received by the syringe adapter 150. Although theconnection member 154 is shown with the patient connector 152, theconnection member 154 may be provided on any suitable component of asystem for the closed transfer of fluids, including, but not limited to,vial adapters, infusion adapters, etc.

The connection member 154 is a projection extending radially outwardfrom the patient connector 152. The connection member 154 is received bya recessed portion 156 of the housing 16 of the syringe adapter 150 tosecure the patient connector 152 to the syringe adapter 150 when thepatient connector 152 is received by the syringe adapter 150. Theconnection member 154 is semi-spherical, although other suitable shapesand configurations may be utilized. As shown in FIG. 28, three equallyspaced-apart connection members 154 are provided on the patientconnector 152, although one or more connection members 154 may beprovided. Upon inserting the patient connector 152 into the housing 16of the syringe adapter 150, the second membrane 94 of the patientconnector 152 engages the first membrane 34 of the collet 32 and movesthe collet 32 to the second position as described above in connectionwith syringe adapter 12. As shown in FIGS. 27 and 29, however, when thecollet 32 is transitioned to the second position, the connectionmember(s) 154 engage the housing 16 of the syringe adapter 150 and arereceived within the recessed portion 156 of the housing 16 to furthersecure the patient connector 152 to the syringe adapter 150. To removethe patient connector 152, a user applies an axial force to the patientconnector 152 in a direction away from the syringe adapter 150 such thatconnection member(s) 154 snap out of the recessed portion 156 of thehousing 16 of the syringe adapter 150. The collet 32 will also releasefrom the patient connector 152 in the same manner as discussed above.

Referring to FIGS. 30-35, a syringe adapter 170 and patient connector172 according to a further aspect of the present invention is shown. Thesyringe adapter 170 is similar to the syringe adapter 12 shown in FIG. 1and operates in a similar manner. The syringe adapter 170 of FIGS.25-29, however, includes a different connection arrangement. The syringeadapter 170 includes a lock mechanism 174 movable between an unlockedposition (shown in FIGS. 31 and 32) and a locked position (shown inFIGS. 33 and 34). The collet 32 includes a lock interface 174 that isconfigured to engage the lock mechanism 174 when the collet 32 is in thesecond position and when the lock mechanism 174 is in the lockedposition. The lock mechanism 174 is disengaged from the lock interface176 when the collet 32 is in the second position and when the lockmechanism 174 is in the unlocked position. The lock mechanism 174 ismanually movable between the locked and unlocked positions by a user,although other suitable arrangements may be utilized.

The lock mechanism 174 has a first end 178 and a second end 180 anddefines an opening 182 that is configured to receive the collet 32. Whenthe lock mechanism 174 is in the unlocked position, the first end 178 ofthe lock mechanism 174 protrudes from the housing 16 and the second end180 of the lock mechanism 174 is received within the housing 16. Whenthe lock mechanism 174 is in the locked position, the first end 178 ofthe lock mechanism 174 is received within the housing 16 and the secondend 180 of the lock mechanism 174 protrudes from the housing 16. Thesecond end 180 of the lock mechanism includes an indicator 184. Theindicator 184 may be a colored portion of the lock mechanism 174 that isdifferent than the remaining portion of the lock mechanism 174. Thecolored portion may be a dominant color, such as red. The lock mechanism174 is received within the transverse opening 40 of the housing 16 ofthe syringe adapter 170 and is retained within the housing 16 viaretention portions 186 of the lock mechanism 174 positioned intermediatethe first and second ends 178, 180 of the lock mechanism 174 that engagethe housing 16.

As shown in FIG. 32, when the patient connector 172 is received withinthe syringe adapter 170 with the collet 32 moved to the second position,the collet 32 is received by the opening 182 of the lock mechanism 174.To maintain the collet 32 and the patient connector 172 in the secondposition, the lock mechanism 174 is transitioned to the locked positionsuch that the lock mechanism 174 engages the lock interface 176 of thecollet 32 with the indicator 184 providing an indication of the lockedstatus of the syringe adapter 170.

While this disclosure has been described as having exemplary designs,the present disclosure can be further modified within the spirit andscope of this disclosure. This application is therefore intended tocover any variations, uses, or adaptations of the disclosure using itsgeneral principles. Further, this application is intended to cover suchdepartures from the present disclosure as come within known or customarypractice in the art to which this disclosure pertains and which fallwithin the limits of the appended claims.

What is claimed is:
 1. A syringe adapter comprising: a housing having afirst end and a second end, the first end configured to be secured to afirst container; a cannula having a first end and a second end, thesecond end of the cannula positioned within the housing; and a collethaving a first end and a second end, at least a portion of the colletreceived within the housing, the collet comprising a body defining apassageway, a membrane received by the passageway, and a locking memberconnected to the body of the collet, the membrane comprising a bodyhaving a first end and a second end, the collet is movable from a firstposition where the locking member is open to receive a mating connectorto a second position where radially outward movement of the lockingmember is restricted, wherein the passageway of the body of the colletcomprises a narrowed portion configured to compress a portion of thebody of the membrane.
 2. The syringe adapter of claim 1, wherein thepassageway of the body of the collet comprises a first counterbore, asecond counterbore positioned opposite the first counterbore, and anintermediate portion, the intermediate portion of the passageway of thebody of the collet including the narrowed portion.
 3. The syringeadapter of claim 2, wherein the narrowed portion of the passageway has asmaller diameter than a remaining portion of the intermediate portion ofthe passageway.
 4. The syringe adapter of claim 3, wherein the membranehas a first head portion and a second head portion, the first and secondhead portions extending radially outward from the body of the membrane,the body of the membrane having a first portion having a first diameterand a second portion having a second diameter, the first diametersmaller than the second diameter.
 5. The syringe adapter of claim 4,wherein the intermediate portion of the passageway of the body of thecollet receives the first portion of the membrane.
 6. The syringeadapter of claim 5, wherein the second counterbore of the passageway ofthe body of the collet receives the second portion of the membrane. 7.The syringe adapter of claim 1, wherein the body of the membrane definesa passageway.
 8. The syringe adapter of claim 7, wherein the passagewayof the membrane extends from the first end of the body of the membranetowards the second end of the body of the membrane.
 9. The syringeadapter of claim 8, wherein the passageway of the membrane terminates ata position intermediate the first and second ends of the body of themembrane.
 10. The syringe adapter of claim 2, wherein the membraneincludes a first head portion and a second head portion.
 11. The syringeadapter of claim 10, wherein the first head portion of the membrane ispositioned within the passageway of the collet, and wherein the secondhead portion is engaged with an end of the body of the collet.
 12. Thesyringe adapter of claim 10, wherein the first head portion includes afrusto-conical surface.
 13. The syringe adapter of claim 12, wherein thesecond head portion includes a convex surface.
 14. The syringe adapterof claim 10, wherein the first head portion of the membrane engages thecollet and is positioned within the first counterbore.
 15. The syringeadapter of claim 1, wherein the passageway of the collet has a firstportion and a second portion, the first portion of the passagewayincluding the narrowed portion.
 16. The syringe adapter of claim 15,wherein the first portion of the passageway of the collet has a smallerdiameter than the second portion of the passageway of the collet.